Updated: July 3, 2026

Kentuckiana Integrative Medicine

Kentuckiana Integrative Medicine is a regenerative, integrative, and functional medicine clinic in Jeffersonville, Indiana — directly across the river from Louisville, Kentucky — led by Dr. Rafael F. Cruz, MD. The practice offers medical weight loss, regenerative therapies for pain and injury, IV vitamin therapy, ketamine therapy, and integrative treatments for a wide range of chronic conditions.
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Clinic Profile

Kentuckiana Integrative Medicine (regenmedky.com) offers an entirely personalized treatment approach, serving the Louisville, Kentucky and Southern Indiana areas from a comfortable and inviting office in Jeffersonville. This physician-owned practice focuses on advanced regenerative and functional medicine to get to the root cause of disease.

Kentuckiana Integrative Medicine welcomes patients of any age and offers specialized skills of its founder, Dr. Rafael Cruz, with his more than 24 years of medical experience, along with a clinical team with more than 70 years of combined provider experience.

  • Location: 405 E Court Ave, Suite 102, Jeffersonville, IN 47130
  • Phone Number: (812) 913-4416
  • Business Hours: Monday, Wednesday, Friday: 7:30 a.m.-5:00 p.m. | Tuesday & Thursday: 7:30 a.m.-6:00 p.m. | Saturday & Sunday: Closed
  • Website: regenmedky.com

Background and History

The Kentuckiana Integrative Medicine clinic is the private practice of Dr. Rafael F. Cruz, MD, a medical doctor who became interested in the concept of integrative medicine through his studies in anesthesia and pain clinic practices. During this time, he discovered that there were limitations in conventional treatments, so he decided to delve into regenerative medicine such as prolotherapy. His interests later changed after years of working in the field of emergency medicine.

At this time, he witnessed a lot of preventable illnesses among patients, and therefore, his interest turned towards disease prevention. Today, the practice offers the benefits of both conventional medicine and natural/alternative medicine. It is divided into four divisions: regenerative medicine, integrative medicine, Ketamine Institute, and weight loss and wellness programs.

Services and Programs

The clinic provides an extensive range of treatment methods that help treat chronic pain, enhance metabolic function, and bring balance back to your body.

Medical Weight Loss

  • Weight Management under Doctor Supervision: Weight loss treatment plans provided by a doctor that concentrate not only on fast results but also on the overall well-being.
  • Advanced Prescription Treatment: You will be provided with such prescription medications as Semaglutide, Phentermine, and HCG injections.
  • Metabolic Enhancement: Lipotropic injections for effective fat metabolism.
  • Proper Nutrition Advice: Healthy eating lifestyle treatment plans, along with continuous consultation and pharmaceutical-grade supplements.

Regenerative Medicine

  • Joint Treatments: Joint treatments and joint pain management without surgery.
  • Advanced Injections: Hyaluronic gel joint injections administered using precise fluoroscopic X-ray guidance.

Integrative & IV Therapies

  • Cellular Nutrition: Personalized intravenous vitamin infusions tailored to address chronic fatigue, immune insufficiencies, and illnesses.
  • Oxidative Therapies: Ozone treatment and ultraviolet blood irradiation.
  • Illness Support: Supplements that can help with heart diseases, autoimmune diseases, and chronic fatigue syndromes.

Ketamine Therapy

  • Mind Reset: Ketamine intravenous infusions administered within a VA-approved facility and meant to target difficult to manage depressions, post-traumatic stress disorder, obsessive-compulsive disorder, bipolar disease, migraines, and chronic pain illness.

Additional

  • Fast Appointments: Urgent consultations and telemedicine visits.

Doctors and Medical Professionals

The physicians and clinicians combine years of clinical practice with an empathic patient-centered approach.

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Dr. Rafael F. Cruz, MD, CIME — Founder & Medical Director

With more than 24 years of practicing medicine, Dr. Cruz offers extensive expertise in the field. Dr. Cruz is a Certified Independent Medical Examiner and has a board certification from the American Board of Emergency Medicine. Dr. Cruz specializes in oxidative medicine, ketamine treatments, and non-surgical joint restoration treatments. At his metabolic center, Dr. Cruz focuses on identifying biological reasons behind obesity through premium, highly formulated products of Pure Encapsulations.

Clinical & Support Team

Dr. Cruz has an exceptional clinical team of nurses and medical assistants who bring over 70 years of experience in healthcare. Richell is just one example of such outstanding individuals whose work is praised for its professional communication and warm approach to the patients.

Reviews and Patient Feedback

The clinic has become quite popular in the region owing to the presence of its profile on Google, Yelp, and Facebook. Many clients praise the clinic for having a comfortable atmosphere as well as professional attitude of the clinic staff. In addition to the client’s satisfaction, Kentuckiana Integrative Medicine also states that around 90% of its dedicated weight loss clients have succeeded in reaching their healthy weight levels with significant drops in their blood pressure, cholesterol, and glucose levels.

Testimonials and Quotes

The following testimonial is drawn from the practice’s Yelp presence:

“Excellent experience with Dr. Cruz and Richell, as well as the staff at Kentuckiana Integrative Medicine.” — Reviewer on Yelp

Patients through the clinic’s online forums have continually highlighted how helpful and effective their personalized program for pain and metabolism management was to them, especially with how familiar the staff members were with them.

Pricing and Value Signals

Most therapies at Kentuckiana Integrative Medicine are self-pay, as many integrative and regenerative treatments are not covered by insurance (consultation fees are noted as approximately $300, or $400 for neurological consults). The clinic emphasizes safe, affordable, long-standing weight loss programs and offers free discovery calls. It also provides significant free and discounted patient care as part of its “pay it forward” philosophy. Specific treatment pricing is provided during consultation.

Verification Notes

  • The address of the clinic is 405 E Court Ave, Suite 102, Jeffersonville, IN 47130, serving clients in southern Indiana and Louisville, KY area. The phone number (812) 913-4416 was confirmed at the clinic’s website and Yelp page.
  • The clinic is a single-location medical practice owned by Dr. Rafael F. Cruz, MD, CIME. Dr. Rafael’s credentials, certification, and professional background were confirmed on the official website of the practice.
  • One of the features of the clinic is a medical weight loss program that consists of medications like Phentermine, HCG, Semaglutide, lipotropic injections, and other regenerative and wellness services.
  • Friendly and helpful staff are among the most popular comments made by clients in their reviews, and Richell from the staff is frequently mentioned.
  • Some regenerative therapies may be considered experimental or off-label therapy, but the clinic can be listed in the weight loss directory.
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Kentuckiana Integrative Medicine Contacts

  • 405 E Court Ave #102, Jeffersonville, IN 47130, United States

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