Lowcountry Male Clinic

Clinic Profile

Lowcountry Male (lowcountrymale.com) is a concierge male health network that has nine health center locations located in South Carolina, North Carolina and Georgia. It’s a men’s clinic and is under the exclusive ownership and operation of CEO/Owner Michael Twilley. It offers subscription-based healthcare solutions which encompass aesthetic solutions, anti-aging care, peptide therapy, medical weight loss, erectile dysfunction remedies, and Testosterone replacement therapy (TRT), and more.

Patients are charged a flat fee for any number of visits they make to the doctor’s office and for the unlimited access they have to the treatment prescribed and the associated lab work. The clinic accepts HSA/FSA payments, and provides telehealth services for patients who are eligible. Treatment and medicine can be directly provided to the patients.

General Phone (main line): (850) 801-6253 Website: lowcountrymale.com Hours: Monday – Friday: 8:30 AM – 5:00 PM; Saturday – Sunday: Closed

Background and History

Lowcountry Male’s mission is to provide a need for more specific and accessible men’s healthcare to the Southeast. It started in the Charleston, South Carolina area (the “Lowcountry”) and slowly expanded to include nine clinics operating in nine different states.

The clinic also ranks in the top 1% of men’s clinics in its main markets and is a “Best of Mt. Pleasant” Men’s Clinic for 2022 and 2023, with high scores of patient satisfaction.

The practice is being led by CEO Michael Twilley and operates as a concierge practice whereby patients will be able to access constant care, monitoring and medication support for one monthly fee, versus each visit they make to the practice and each time they use a service provided at the practice.

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Services and Programs

Lowcountry Male operates as a full-service men’s health clinic organized across six service pillars:

Medical Weight Loss:

• GLP-1 Weight Loss Management — semaglutide (Wegovy®, Ozempic®) and tirzepatide (Zepbound™, Mounjaro®); patients lose on average 15% of body weight; lowers A1C and blood pressure
• Phentermine — prescription appetite suppressant
• Fat Burning Shots (B12) — lipotropic / B12 injection support

Testosterone Replacement Therapy (TRT):

• Offers different treatment options including Testosterone injection (cypionate) and oral medications (Kyzatrex®), fertility preservation options (enclomiphene or Clomid) and pellet therapy (administered multiple times per year). A majority of plans also offer assistance with estrogen management, if required.

Erectile Dysfunction:

• Oral medications (sildenafil, tadalafil) as well as more advanced treatments include compounded troches, Trimix/Quadmix injections, shockwave therapy and P-Shot with PRP and performance recovery treatments.

Anti-Aging & Longevity:

• This will consist of IV therapy, NAD+ therapy, metformin, rapamycin, methylene blue, sermorelin, and PRP joint treatments. These are formulated to support long term well-being, cellular health and energy promotion. For continuous monitoring, full lab testing is also available.

Hair Restoration:

• Provides PRP hair restoration, stem cell therapy (DE|RIVE), topical hair regrowth sprays, supplements (Nutrafol) and complete hair restoration programs for hair thinning or loss.

Aesthetics:

• Includes Laser Hair Removal, Medical Grade Skin Care Products (ZO Skin Health), Botox, Xeomin, Dermal Fillers (Juvederm) and HydraFacials.

Peptides:

• Provides healing and performance peptides, such as sermorelin and other personalized peptide protocols based on the individual patient’s objectives.

Doctors and Medical Professionals

Doctors and clinical staff are licensed for all clinics. Michael Twilley serves as CEO/Owner of the practice. Individual doctors’ names are not made public, and the medical team is in charge, from initial consultation to long term follow-up care.

There are four steps to the care process:

1. Initial consultation occurs at site with a physical exam, health history, InBody metabolic scan and lab testing. 
2. Treatment plan is made based on the results.
3.  Afterwards, medications and therapies are given, often also at home. 
4. Then, patients are followed up on with regular check-ups and follow-up labs to check for progress and make necessary adjustments.

Reviews and Patient Feedback

In 2023, Lowcountry Male won the “Best of Mt. Pleasant” Men’s Clinic award and in 2024, the award was given again. Feedback from patients is generally positive about convenience, regular follow-up and the ease of the subscription model, across the locations.

The clinic also has an active instagram feed, @lowcountrymale, and some patient education posts are posted regularly, as well as results.

Testimonials and Quotes

Testimonials are not prominently featured on the clinic’s main site. Instead, they publish their experience and success stories on the Internet through social media, especially Instagram – @lowcountrymale. If patients wish, they are encouraged to share their journeys.

Pricing and Value Signals

The pricing model for Lowcountry Male is a new subscription model, as opposed to a traditional billing model. The first consultation is $199, and it includes a complete physical exam, an InBody metabolic analysis and a 1-hour consultation with a physician.

Various memberships for treatment and intensity exist for each month. In other words, the pricing is done on the following:

Monthly Subscription Plans:

As for all plans, patients can visit the doctor as many times as necessary, their lab tests will be tracked, prescription management and medical support will be provided throughout the plan. Will take HSA/FSA payments and some may even have insurance eligibility available as well, in addition to the service. A discount promotion of $100 off the first visitation. 

Verification Notes

• All nine addresses and contact information come straight from the official Lowcountry Male website footer (lowcountrymale.com). CEO/owner Michael Twilley verified via BBB business profile.
• All plan pricing is from the Plans and Pricing page (lowcountrymale.com/mens-low-t-plans/) accessed June 2026.
• The consultation’s initial cost of $199 is on the Plans and Pricing page.
• “Best of Mt. Pleasant” 2023 and 2024 awards come from the clinic’s About section.
• HSA/FSA verification comes from the HSA/FSA badge at the website footer.
• Work hours (Mon-Fri 8:30-5:00) verified via Yelp listings for all locations.
• Names of individual physicians are not provided by the clinic on its website – that is an accurate reflection of what is provided.
• Fort Mill, SC location advertised as “Charlotte Metro” or Charlotte, NC – it is reflected accurately as stated by the clinic itself on its website.