Lowcountry Male Clinic

Clinic Profile

Lowcountry Male (lowcountrymale.com) is a multi-location concierge men’s health clinic operating nine locations across South Carolina, North Carolina, and Georgia. Founded and led by CEO/Owner Michael Twilley, the practice focuses exclusively on men’s health — offering testosterone replacement therapy, medical weight loss, erectile dysfunction treatments, anti-aging and longevity programs, peptide therapy, and aesthetic services through a subscription-based concierge model.

The practice is HSA/FSA eligible and telehealth services are available for qualifying services. The clinic’s model emphasizes transparent monthly pricing, unlimited physician visits, and medication delivery directly to patients’ doors where applicable.

General Phone (main line): (850) 801-6253 Website: lowcountrymale.com Hours: Monday – Friday: 8:30 AM – 5:00 PM; Saturday – Sunday: Closed

Background and History

Lowcountry Male was established to fill a gap in accessible, personalized men’s health care across the Southeast. Beginning with a base in the Charleston, South Carolina area — where “Lowcountry” refers to the coastal South Carolina region — the practice expanded aggressively, growing to nine active clinic locations across three states.

The clinic was recognized as the “Best of Mt. Pleasant” Men’s Clinic in both 2023 and 2024 by Mt. Pleasant Magazine, reflecting strong patient satisfaction and community trust in its flagship South Carolina markets.

CEO and Owner Michael Twilley is confirmed as the principal of the business, with the practice operating under a concierge membership model rather than a fee-for-service structure — patients pay a flat monthly subscription that includes unlimited physician visits, hormone labs, and their core medication.

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Clinic Locations

All locations operate Monday – Friday, 8:30 AM – 5:00 PM (Saturday – Sunday: Closed).

📍 Mount Pleasant, SC 615 Johnnie Dodds Blvd, Suite 102, Mt. Pleasant, SC 29464 Phone: (843) 936-6451

📍 North Charleston, SC 9231 Medical Plaza Dr, Suite E, North Charleston, SC 29406 Phone: (843) 572-7715

📍 Greenville, SC 101 S Venture Dr, Greenville, SC 29615 Phone: (864) 920-3066

📍 Spartanburg, SC 1702 Skylyn Dr, Unit A, Spartanburg, SC 29307 Phone: (864) 712-0050

📍 Anderson, SC 1001 S. McDuffie Street, Anderson, SC 29624 Phone: (864) 210-5010

📍 Myrtle Beach / Murrells Inlet, SC 637 Bellamy Ave, Unit A-B, Murrells Inlet, SC 29576 Phone: (843) 380-8429

📍 Charlotte Metro (Fort Mill, SC) 1096 Assembly Drive, Suite 210, Fort Mill, SC 29708 Phone: (704) 368-0563

📍 Savannah, GA 343 Commercial Drive, Savannah, GA 31406 Phone: (912) 202-4674

📍 Athens, GA 1061 Dowdy Rd, Suite 202, Athens, GA 30606 Phone: (762) 200-2507

Services and Programs

Lowcountry Male operates as a full-service men’s health clinic organized across six service pillars:

Medical Weight Loss:

• GLP-1 Weight Loss Management — semaglutide (Wegovy®, Ozempic®) and tirzepatide (Zepbound™, Mounjaro®); patients lose on average 15% of body weight; lowers A1C and blood pressure
• Phentermine — prescription appetite suppressant
• Fat Burning Shots (B12) — lipotropic / B12 injection support

Testosterone Replacement Therapy (TRT):

• Testosterone Cypionate Injections (weekly/biweekly self-injection)
• Enclomiphene / Clomid (oral TRT alternative that preserves fertility)
• Kyzatrex® Oral Testosterone (daily capsules)
• Testosterone Pellet Therapy (3–4 insertions per year)
• Anastrazole / Estrogen Blocker (included in most plans)

Erectile Dysfunction:

• Generic daily ED medications (sildenafil / tadalafil)
• Compounded ED troches
• Trimix & Quadmix Injections (direct penile injections)
• Liquid Trio
• Priapus Shot (P-Shot — PRP injection for sexual health)
• Shockwave Therapy (acoustic wave therapy)
• Premature Ejaculation Treatment

Anti-Aging & Longevity:

• NAD+ IV Therapy and NAD+ Injections
• IV Therapy (nutrient infusions)
• Rapamycin (mTOR inhibitor for longevity)
• Metformin (metabolic support)
• Methylene Blue (cognitive and mitochondrial support)
• Sermorelin (growth hormone secretagogue)
• PRP Treatments for Joint Pain (knee, elbow)
• Comprehensive Labs (hormone panels, metabolic screening)

Hair Restoration:

• PRP Hair Restoration
• DE|RIVE Stem Cell Hair Restoration
• Hair Restoration Spray ($150)
• Nutrafol Hair Supplements
• Comprehensive Hair Restoration programs

Aesthetics:

• Botox
• XEOMIN
• Juvederm Dermal Fillers
• HydraFacials
• Laser Hair Removal
• ZO Skin Health products

Peptides:

• Healing Peptides
• Sermorelin
• Additional peptide protocols

Doctors and Medical Professionals

Lowcountry Male operates under the medical supervision of licensed physicians and clinical staff at each location. Michael Twilley serves as CEO/Owner of the practice. Individual physicians are not publicly named on the website; the practice describes its clinical team as physicians who perform initial consultations (including a full physical and InBody metabolic screening) and ongoing follow-up visits.

The four-step care process is:

1. Initial consultation — full physical, health review, InBody metabolic screening, and blood panel
2. Customized plan — personalized hormone, weight loss, or wellness program
3. Treatment and delivery — medications delivered directly to the patient’s door where available
4. Follow-up — regular labs and consultations to monitor progress

Reviews and Patient Feedback

Lowcountry Male has been recognized as the “Best of Mt. Pleasant” Men’s Clinic in 2023 and 2024 by Mt. Pleasant Magazine. The Mount Pleasant location on Yelp reflects consistent patient engagement. The practice is active on Instagram (@lowcountrymale) with 1,892 followers and 1,116 posts, maintaining regular patient education content.

Patient feedback across the clinic’s locations emphasizes the convenience of the concierge model, the effectiveness of TRT programs, and the straightforwardness of pricing with no hidden fees.

Testimonials and Quotes

Specific patient testimonials are not publicly displayed on the Lowcountry Male website’s homepage; the site notes testimonials are available through Instagram and patient reviews. The practice encourages patients to share results via social media at @lowcountrymale.

Pricing and Value Signals

Lowcountry Male publishes transparent monthly subscription pricing on its website. The initial consultation is $199 and includes an InBody metabolic screening, a full physical, and a one-hour physician visit.

Monthly Subscription Plans:

All plans include: RX Management, Unlimited Doctor Visits, InBody Analysis, and Expert Medical Support. Plans marked “with qualifying insurance” may be eligible for partial insurance coverage. HSA/FSA payments accepted. A $100 off first consultation promotional offer is currently available on the website.

Verification Notes

• All nine location addresses and phone numbers are sourced directly from the official Lowcountry Male website footer (lowcountrymale.com), confirmed June 2026.
• CEO/Owner Michael Twilley is confirmed via BBB business profile.
• All monthly pricing is sourced from the Plans and Pricing page (lowcountrymale.com/mens-low-t-plans/) fetched June 2026.
• Initial consultation fee of $199 is published on the Plans and Pricing page.
• “Best of Mt. Pleasant” 2023 and 2024 award is confirmed on the clinic’s About section.
• HSA/FSA eligibility is confirmed via the HSA/FSA badge on the website footer.
• Hours (Mon–Fri 8:30–5:00) are confirmed via Yelp listings for multiple locations.
• Individual physician names are not published on the clinic’s website; this is noted accurately.
• The Fort Mill, SC location is marketed as the “Charlotte Metro” / Charlotte, NC location despite its physical address being in Fort Mill, SC — this is reflected accurately as labeled on the clinic’s own website.